I've been riding the 35mm AS TR for the last two years, with approximately 10,000 miles on two pairs, 90% on road and 10% on gravel. Not one flat that I had to repair. These tires are fast, comfortable, grippy, and durable. The tradeoffs for those qualities are some weight (mostly due to the 35mm size) and cost, neither of which is significant in relation to the benefits. I used to think that flatting once a month was part of the experience of riding a bike, or I could stretch that two months if I rode tires that felt like bricks (28mm Conti 4-Season or Schwalbe Marathon). Riding these tubeless tires is the most significant improvement in cycling equipment I've experienced in the last three decades. I'll go back to downtube friction shifters before I give up these tires. I used some other fast gravel/all-road tires before these, and while they were ok (Schalbe G-one variations and others) they were not as fast and wore out faster. I will switch to some knobbier and fatter tires if I'm going to be mostly off-road, but otherwise this is peak cycling tire for my needs.
Long time GP, GP 4000, and now GP 5000 TR tire user. For the weight, these are the most durable tires, long wearing and great grip. I'm 185 lbs and ride in the PNW, often crummy road surfaces and sometimes wet. I'm running 700x30 on 25mm internal width rims at 58/62 psi. These are still comfortable (I down sized from 32s) but, handle better on high speed turns, as I don't feel the tire flexing between the road and rim. The right tire, rim and PSI is crucial, and these are my numbers. I've ridden Schwalbe G1, Vredestein, Maxxis High Road, and top end Vittoria tires, but always go back to Continental GPs. Great tire, great ride.
Probably the best tire I've used in the 30+ years of cycling. I've used Michelin for years and turned to Conti's after recommendations. Going from tubed to tubeless was the next best choice in the evolution of the tire. These Conti GP 500 AS TR have been a welcome change and have performed well over 7000 miles of use. I'm getting about 4k miles on the tires. There has been only one negative, but I'm not sure if it was the tire or a one-off. While stopping for a rest, at my vehicle, the bike in the full sun, on asphalt, about 80 degrees, the front tire spontaneously had a blow out. Latex (Stans) was everywhere. Probably just a one-off.
I bought these tires because Panaracer decided to quit making their Small Knobs in 43mm. The Continentals say 45mm, but they look to be the same width as the SK 43s. I've only had them on the bike for two months but so far so good. They were a little pricier than the Panaracers and I gave them 4 stars just because I haven't had them long enough to know how durable they are. Grip is good, slightly more aggressive than the SKs, but still low profile enough to roll well when on pavement.