I've been using these tubes on my go-to road bike for about 1.5 years now, and overall, I really like them, and will continue to use them. They're reasonably light, roll very nicely, and are quite puncture-resistant.
However, I do not quite trust the valve cores. They are loose when they come shipped, and you have to tighten them before the first use, which is not a deal-breaker, but still worth noting. I use Leyzyne pumps, which are threaded, and with these tubes you need to quickly re-tighten the valve cores every time you inflate your tires, which, again, is not a deal-breaker, but still annoying. I have not yet had a valve failure, but these things are apparently 3-D printed, not metal, and I can imagine a total valve failure happening if you're not attentive.
If they came with non-removable valve cores, I'd be a lot happier with them, but, overall, they're very good: they perform almost as well as latex, but are even lighter, and they're more durable and retain air better than butyl tubes.
I've been a fan of Tyrewiz ever since they first came out, because it helps me keep tabs on my tire pressure and keep it all very consistent. Sometimes I'd feel the rear of the bike step out just a hair. In the past I'd stop and give the rear tire a pinch to make sure I'm not imagining things. With Tyrewiz, I just glance at my cyclecomputer and keep rolling, no big deal. It was also fun and educational to see my tire pressures go up about 1 psi as they warmed up riding in the sun.
Like another reviewer, I have mixed feelings about this 2.0 model. For starters, the price is very high and on top of that you have to measure your and buy special valve stems. Those valves are a significant extra cost, can be difficult to find (I waited for months in one case) and you need to use a special tool when you're adding sealant through the valve stem.
Also, the battery is unchanged. This is a big miss, because the old battery never lasted long enough on the 1.0 model. If you have just one bike, maybe no big deal, but if you have a few it feels like you're constantly swapping them out. I really wish they would have taken the opportunity to switch to a longer-lived battery. At least the batteries are easier to change than before (see below).
Depending on what rim you have, getting these to sit nicely might be a challenge. Some rims (like the Light Bicycle AM930S) have rippled internal diameters. If you have one of these rims, you'll need to make a run to the hardware store to buy some rubber washers to fill the valley between spoke holes.
Cyclecomputer support is still kind of hit and miss. Garmins only support Tyrewiz through the ConnectIQ app. This app used to be extremely flaky. It seems to be working better now, but I'd like to see real factory support from SRAM on this. On Hammerhead Karoo, the support is quite good, but you have to consume a whole data field for each tire. I'd really prefer to see one field service both tires simultaneously.
I'm also concerned whether the protocol and pairing will work correctly if other Tyrewiz riders are in the vicinity. Rumor has it you might pick up someone else's tire pressures, which would be incredibly annoying.
On the positive side, this form factor seems far more robust than the goofy "flag" style from the 1.0 product. I actually had the flag rotate once and snag on something while descending a flight of stairs, breaking the valve and causing an instant flat. Not cool. This isn't an issue at all on the 2.0 product.
The 1.0 product was really fiddly the change batteries, and the battery contact points were also super fiddly. I used to have to frequently use a jeweler's screwdriver to gently bend the contacts so they'd keep the battery connection alive. Knock on wood, the 2.0 version is very easy to change batteries and the contacts are working better.
As another reviewer noted, one downside of the 2.0 form factor is that using tubes with these is out of the question. I never tried tubes with the old version, but given the "flag" form factor, they should work fine.
Overall, these Tyrewiz 2.0's are better than the 1.0 versions, but they're more expensive and not as much better as I hoped for. The value proposition is kind of meh, so I'd only recommend these to someone who really wants live telemetry of their tire pressures.
I use these everyday. They mount up easy with my old hands only. Inflate easily and hold air like no other tire I've owned. They roll and corner very fast. I had another set from a major tire company and when I mounted and rode with these, I immediately felt I could corner better and roll faster. They were just a tad harsher which I think maybe because once mounted they were exactly 32 mm as the other set measured 34 even though they were both 32 mm tires.
What can I say that hasn't already been said about these very durable tires. I rode across the country (on the ACA TransAm trail) on these tires without a single flat! I use it on all my bikes because they are extremely flat resistant and they last a long time. They do run on the "heavy" side, but the durability and longevity they provide is a tradeoff I can easily live with (I'm obviously a "tourist" and not a "racer"). I much prefer this solution to the mess and hassle of tubeless tires.