After reading an article in Slowtwitch.com regarding tire sealants, Orange Seal rated the best in punctures. And this was for tubes in clinchers.
I run Continental GP4000sII tires (70025) with tubes. I had been experiencing a flat event about every 400 to 500 miles before using Orange Seal. On my first ride after installing Orange Seal, I had a puncture that sealed itself. I didn't notice an event until I got home and noticed the latex had been spewed out but was not stopped. I found the rock chip and removed it. It spewed for about 5 seconds and then sealed.
Since then, I have had two tire cuts that the sealant would not seal. However, I have not had a puncture causing a flat since installing the sealant.
I highly recommend this.