I replaced the pulley wheels on my Shimano Ultegra 6800 rear derailleur after about 10k miles. Shifting immediately became more accurate and drivetrain much quieter. Definitely recommended if you haven't changed these in a while.
If your derailleur isnt shifting as precisely as it used to it might be your the pulleys. These pulleys work extremely well and last a good while. They are a great value. Make sure you install the pulleys in the proper positions. They about the same on first glance but they are different. Consult the instructions for top and bottom positions.
I tried being a cheapskate and buying some cheaper non-OEM pulley's on Amazon. Don't.
If you have an Ultegra 6800 rear derailleur, these pulleys are your best and only serious option, unless you want annoying squeaks and probable watt losses.
These pulley's may not be something ground breaking, but you just need them because they are the product that works when your old pulley's get beat up too much.
Also, these are a wear item, so I would much rather replace these than another component, but make sure if you are riding a lot that you periodically pull these out and give them a cleaning and ensure that they are spinning freely. I ride quite a lot, so I know that they are going to be working hard in my drive train.