I got this jersey for the colder than normal winter we are having in So Cal this year. I have worn it in high 30's with a long sleeve base layer and have been totally comfortable while my buddies have 2 shirts and a vest. It is great to wear so little, be so warm and not be soaked in sweat. This jersey breathes really well. I will probably buy another one when it goes on sale again and be set for the next 6 years. The warmest I have ridden in this thing is about 58 or 60. That gets a little warm with a thermal base layer. A regular base and you would be golden.
I wear my Pearl Izumi pro escape thermal jersey for cycling in cold weather with an underlayer and in cool weather without additional layers. it is comfortable with a good fit. The price was significantly lower than other on-line sites.
I bought this jersey to get away from being a mobile billboard in the winter. I'm very happy with the fit, full zipper and multiple pockets. I often wear this jersey with a light vest if rain is expected.