I have used Conti GP4000s for years and this is the first tire I like better. It has better ride comfort and better grip. The downside is it cuts easily.In addition you must learn some new techniques to get it mounted. The initial bead must be centered in the rim and then you should chase the other bead around the rim until you are able to mount it with your thumbs. A Joe Blow Booster pump (or similar) is required to pop the beads onto the rim - a normal floor pump won't work. A proper amount of sealant is necessary for optimum performance. The increased safety of tubeless technology is worth the hassle.
I have had these on Cosmic Carbon UST wheels for about 10 months now. The front tire is great, no issues and no cuts! The first rear tire suffered a full thickness cut all the way from bead to bead so I can't really say that any tire would have fared better but the one I bought to replace it has been problematic. It's worn very quickly and has had so many little cuts that the sealant is constantly oozing. I've also seen bubbles of air that collect under the compound of the tire, as though air can track out of the space between the rim and the tire and actually collect in between the layers of rubber. I would also add that the set up is not really as easy as it looks in the video!